The image shows a nucleosome clutch (blue). Eukaryotic nucleosomes, each consisting of eight histones (green), help structure chromosomes by compacting DNA into fibers. Chromatin compaction follows a hierarchical model where nucleosomes form a beads-on-string structure. It is indicated that nucleosomes are grouped in discrete domains along the chromatin fiber, which are termed nucleosome “clutches”. These clutches are interspersed with nucleosome-depleted regions. Differentiated cells contain larger and denser clutches than stem cells. Therefore, nucleosome clutches regulate the accessibility of DNA for transcriptional purposes.
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