HIF-1a ARNT complex

The image shows the HIF-1a (red) and ARNT (yellow) complex (grey). It binds to DNA on specific hypoxia response elements (HRE) (blue).

HIF-1a ARNT complex

SKU: cal20_01_1 Categories:images, protein Tags:arnt, arnt complex, arnt-1a, biochemistry, biological, biology, biomedical, genetics, hypoxia, molecule, oxygen, protein complex, structure

Description

Description

The image shows the HIF-1a (red) and ARNT (yellow) complex (grey). It binds to DNA on specific hypoxia response elements (HRE) (blue). Cells respond to reduced oxygen levels through the activation of a particular set of genes, including those involved in energy metabolism and apoptosis, as well as genes whose gene products are related to increased oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in tumor angiogenesis and the pathophysiology of ischemic disease. miRNAs regulate the HIF switch during hypoxia.

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