Description

The image illustrates p53 guardian of the genome. Also known as TP53, it is a classic tumor suppressor gene whose activation induces apoptosis, cell cycle arrest, or senescence in response to distinct stimuli, including DNA damage or aberrant oncogene activation. A p53 mutant protein goes hand in hand with higher gene expression. Consequently, higher protein levels of p53, due to a mutation, can also be regarded as an immunogenic trigger.

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