This video shows the growth of alpha-synuclein fibers ( pink), also called aSyn, in a neuron(yellow). aSyn is a protein abundantly expressed in the brain, mainly within presynaptic neurons, with the principal role of vesicle trafficking. Misfolding of this protein is shown to induce aggregation and the formation of aSyn fibrils. Increasing evidence shows the formation of these aggregates is the causative agent in many neurodegenerative diseases termed synucleinopathies, including Parkinson’s disease and multiple system atrophy (MSA).
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